Genetic Study on Mandibular Prognathism by Multivariate Analysis

Mandible in Mandibular Prognathism

Department of Orthodontics, School of Dentistry, National Taiwan University, Taipei; Department of Orthodontics, School of Dentistry, Kaohsiung Medical University, Kaohsiung; Institute of Biomechanical Engineering, National Cheng Kung University, Tainan. Received: 3 May 2002. Revised: 3 June 2002. Accepted: 9 July 2002. Reprint requests and correspondence to: Dr. Hong-Po Chang, Department of Or...

Genetic variation in myosin 1H contributes to mandibular prognathism.

INTRODUCTION Several candidate loci have been suggested as influencing mandibular prognathism (1p22.1, 1p22.2, 1p36, 3q26.2, 5p13-p12, 6q25, 11q22.2-q22.3, 12q23, 12q13.13, and 19p13.2). The goal of this study was to replicate these results in a well-characterized homogeneous sample set. METHODS Thirty-three single nucleotide polymorphisms spanning all candidate regions were studied in 44 pro...

Mandibular prognathism caused by acromegaly – a surgical orthodontic case

A 22-year-old man presented for orthodontic surgery because of mandibular prognathism. Clinical symptoms suggested acromegaly, and diagnosis was verified by an endocrinologist as well as by radiograph. Bilateral mandibular prognathism often represents the first and most striking physical characteristic of acromegaly; usually, it is also the main reason why patients seek help from orthodontists ...

Chin cup therapy for mandibular prognathism.

Candidate Gene Analyses of Mandibular Prognathism

Causation of a disease and a symptom generally is classified as genetic inheritance and environmental factors. A disease caused by a single gene disorder is defined as a disease that is attributed to a monogenic factor. A single gene disorder has been reported in more than 3,000 hereditary diseases. On the other hand, a polygenic or multifactorial disease is attributed to some susceptibility ge...